Part 1. Overview Information

Participating Organization(s) National Institutes of Health (NIH)

Components of Participating Organizations Office of Strategic Coordination (Common Fund)

Notice of Funding Opportunity Description This Notice of Funding Opportunity (NOFO) is developed as a Common Fund Initiative through the Office of the NIH Director, Office of Strategic Coordination. All NIH Institutes and Centers participate in Common Fund initiatives. The NOFO will be administered by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) on behalf of the NIH.

Funding Opportunity Title Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed)

Activity Code U24 Resource-Related Research Projects – Cooperative Agreements

Announcement Type New

Related Notices

• Check for any recent Notices of NIH Policy Changes that may impact application requirements.

Funding Opportunity Number (FON) RFA-RM-27-015

Companion Funding Opportunity

• RFA-RM-27-011, U01 Research Project (Cooperative Agreements)
• RFA-RM-27-012, UG3/UH3 Phase 1 Exploratory/Developmental Cooperative Agreement
• RFA-RM-27-013, UG3/UH3 Phase 1 Exploratory/Developmental Cooperative Agreement
• RFA-RM-27-014, U54 Specialized Center (Cooperative Agreements)

Number of Applications See Part 2, Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93.310

Funding Opportunity Purpose The overarching goal of this NOFO and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI‑based clinical decision support (CDS) tools. PRIMED‑AI CDS tools integrate clinical imaging with other multimodal health data to enhance care for patients with a wide range of health conditions. The program seeks to catalyze adoption of AI‑based CDS tools into clinical workflows to enable novel personalized medicine strategies.

The purpose of this NOFO is to create a Logistics Center for the PRIMED‑AI Program to facilitate and coordinate PRIMED‑AI activities to maximize impact for the PRIMED‑AI community. Within the Logistics Center, three integrated Cores will serve the functions of Administration, Evaluation, and Outreach for the PRIMED‑AI Consortium. It is expected that the Logistics Center will work closely with other PRIMED‑AI consortium members to collect, curate and disseminate information regarding tools developed by the PRIMED‑AI award recipients, and will facilitate widespread access and awareness across the relevant scientific, patient, and clinical communities.

Funding Opportunity Goal(s) The Office of Strategic Coordination (Common Fund) supports research and other projects that will accelerate fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments.

Key Dates

Item	Date
Posted Date	June 30, 2026
Open Date (Earliest Submission Date)	September 02, 2026
Application Due Dates	October 02, 2026
Expiration Date	October 03, 2026
Scientific Merit Review	March 2027
Advisory Council Review	May 2027
Earliest Start Date	July 2027

All applications are due by 5:00 PM local time of the applicant organization. No late applications will be accepted.

Required Application Instructions

Applicants must follow the Research (R) Instructions in the How to Apply - Application Guide except where instructed otherwise in this NOFO or in a NIH Guide notice. Conformance to all requirements is required and strictly enforced. Several submission options are available through Grants.gov:

1. Use the NIH ASSIST system to prepare, submit and track your application online.
2. Use an institutional system‑to‑system (S2S) solution to prepare and submit your application to Grants.gov and eRA Commons to track your application.
3. Use Grants.gov Workspace to prepare and submit your application and eRA Commons to track your application.

Table of Contents

• Part 1. Overview Information
• Key Dates
• Part 2. Full Text of Announcement

Part 2. Full Text of Announcement

Section I. Notice of Funding Opportunity Description

Purpose

The Logistics Center will provide the administrative infrastructure necessary to facilitate and coordinate PRIMED‑AI activities to maximize the impact of the PRIMED‑AI Program. Within the Logistics Center, three integrated Cores will serve the functions of Administration, Evaluation, and Outreach. The Logistics Center is responsible for management of steering committee (SC) meetings, advisory boards, workshops, community interfaces, outreach, and coordination of teaming activities in consultation with NIH PRIMED‑AI staff. In addition, the Logistics Center will work closely with the Validation Center to maintain strong communication and cross‑pollination across the PRIMED‑AI Consortium. Finally, the Logistics Center is expected to develop and manage a PRIMED‑AI web portal to showcase tools developed as a result of the PRIMED‑AI Consortium.

Background

Clinical imaging plays a pivotal role in diagnosis, treatment, and assessment of health outcomes; however, it is often utilized in isolation from other types of data during the development of AI‑based CDS tools. Current AI applications typically leverage a single imaging modality from radiological or ophthalmological sources. Because health is shaped by a variety of interconnected factors—clinical, biological, genetic, environmental and social—the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED‑AI) Program seeks to integrate clinical imaging with relevant, complementary multimodal data (MMD). The overarching goal of the PRIMED‑AI Program is to catalyze the development and adoption of innovative AI‑based CDS tools into clinical workflows.

Prior to applying, applicants are encouraged to check the PRIMED‑AI Program website for updates to relevant FAQs and informational webinars, and to read all companion NOFOs to ensure they are aware of the goals and responsibilities of all PRIMED‑AI award recipients.

Key Terms used in PRIMED‑AI Program (listed alphabetically):

• Clinical decision support (CDS) tool – a software, computational model, or digital system incorporated into clinical workflows to assist in determining a course of action related to patient care.
• Clinical imaging – any FDA‑approved imaging modality used in patient care, including radiologic, ophthalmologic, endoscopic, dermatologic imaging, and video.
• DICOM standard – Digital Imaging and Communications in Medicine standard, strongly encouraged but not required.
• Harmonization – process of bringing together data from different sources and ensuring consistency, comparability, and compatibility.
• Interoperability – ability for AI models and associated data/metadata to be understood and work across different AI platforms and health systems.
• Multimodal data (MMD) – data from multiple sources that may include multiple clinical imaging modalities and non‑imaging health data (EHR, EEG, EKG, lab results, wearable sensors, medical reports).
• Playbook – collection of actionable guidelines, standardized protocols, and/or SOPs for reliable development and deployment of multimodal CDS tools.
• Precision Medicine – healthcare approach that uses individual patient information to guide, tailor, and optimize medical decisions.
• PRIMED‑AI Consortium – members of PRIMED‑AI excluding NIH program staff.
• Uncertainty Quantification – measuring or quantifying the impact of uncertainties in complex systems, including confidence in outcomes predicted by multimodal AI models.
• Validation – analytical/technical validation based on evaluation of algorithmic performance; clinical validation tested on wider real‑world populations.
• Verification – assessment of data integrity and model construction for appropriateness within the intended use.

Key Requirements of the Logistics Center

Administrative Core:

• Provide logistical and administrative assistance for PRIMED‑AI Steering Committee (SC) and working group meetings, conference calls, workshops, and in‑person annual consortium meetings.
• Prepare documents, develop policies, and provide recordkeeping for the PRIMED‑AI Consortium.
• Coordinate with the Validation Center to develop and implement standard procedures for data and metadata collection, storage, sharing, and subproject management.
• Use restricted funds (see Section IV) to support research teaming projects addressing critical needs in the PRIMED‑AI Program pipeline (e.g., underutilized data, robustness, CDS tool user interfaces).
• Use restricted funds to support development of innovative curricula and outreach activities facilitating communication between physicians, data scientists, and patients on PRIMED‑AI topics.

Evaluation Core:

• Develop and manage an external advisory group to provide feedback on the spectrum of issues from data science to clinical uses and implications of multimodal AI CDS tools and resources.
• Provide timely reports to NIH staff on activities and progress made by the PRIMED‑AI Consortium; maintain and make accessible all significant related documents, including policies, guidelines, records, assets, publications, and meeting minutes.

Outreach Core:

• Implement a PRIMED‑AI Consortium‑wide data and resource sharing infrastructure via development of a web portal that ensures sustainable sharing and coordination between PRIMED‑AI members.
• Interact with other governmental AI‑infrastructure efforts as appropriate (e.g., Genesis Mission).
• Promote clinical AI adoption and innovation through interaction with the healthcare and AI community.

Additionally, the Logistics Center will be responsible for developing a PRIMED‑AI Consortium consensus policy document covering data sharing, security, privacy, ethics, data sequestration, AI‑readiness, error mitigation, technical management, subproject lifecycle management, data and model interoperability, collaboration opportunities, stakeholder engagement, operational guidelines, etc. These policies apply to all award recipients and external groups wishing to utilize PRIMED‑AI resources.

Because of the expertise needed to manage the Logistics Center and the collaborative nature of this Center, a multiple PD/PI (multi‑PI) application is required.

See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument Cooperative Agreement: a financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.

Application Types Allowed New

Clinical Trial? Not Allowed: only accepting applications that do not propose clinical trials.

Funds Available and Anticipated Number of Awards The NIH Common Fund intends to commit approximately $750,000 in FY2027. One award is anticipated, contingent upon availability of funds and receipt of a sufficient number of meritorious applications.

Award Budget Application budgets are limited to $575,000 direct costs for the first year and up to $2,500,000 direct costs per year for the remaining four years of the project. Requested budgets need to reflect the actual needs of the proposed project.

Award Project Period The scope of the proposed project should determine the project period; the maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

• Higher Education Institutions (all types)
  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education
• Nonprofits Other Than Institutions of Higher Education
  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
• For‑Profit Organizations
  • Small Businesses
  • For‑Profit Organizations (Other than Small Businesses)
• Local Governments
  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
• Federal Governments
  • U.S. Territory or Possession

Other

• Independent School Districts
• Public Housing Authorities/Indian Housing Authorities
• Native American Tribal Organizations (other than Federally recognized tribal governments)
• Faith‑based or Community‑based Organizations
• Regional Organizations

Foreign Organizations/Foreign Collaborations Non‑domestic (non‑U.S.) Entities (Foreign Organizations) are not eligible to apply. Non‑domestic components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant Organizations

• System for Award Management (SAM) – active registration, renewal at least annually; includes assignment of a CAGE Code (domestic) or NCAGE Code (foreign).
• Unique Entity Identifier (UEI) – issued as part of SAM.gov registration; must be used for all registrations and on the grant application.
• eRA Commons – organizations must identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account.
• Grants.gov – requires an active SAM registration.

Program Directors/Principal Investigators (PD/PI)

• All PD/PI must have an eRA Commons account.
• All PD/PI must be registered with ORCID; the eRA Commons personal profile must be linked to a valid ORCID ID.

Eligible Individuals (PD/PI) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the PD/PI is invited to work with their organization to develop an application.

Effective management will require a significant commitment by the PD/PI(s). A multi‑PD/PI application is required – one PD/PI is expected to commit at least 2 person months annually and the other(s) should devote at least 1 person month each.

2. Cost Sharing

This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

Number of Applications Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time.

Section IV. Application and Submission Information

1. Requesting an Application Package

The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system‑to‑solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO.

2. Content and Form of Application Submission

Applicants must follow the Research (R) Instructions in the How to Apply - Application Guide except where instructed otherwise in this NOFO, a policy notice, or other notice from the NIH Guide for Grants and Contracts. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced.

Sections V‑VIII (brief)

• Section V. Application Review Information – describes peer‑review process, criteria, and scoring.
• Section VI. Award Administration Information – covers post‑award requirements, reporting, and NIH stewardship.
• Section VII. Agency Contacts – provides contact information for scientific/research and grants management contacts.
• Section VIII. Other Information – includes award authorities, regulations, and links to the PRIMED‑AI Program website and companion NOFOs.

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